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Materials and Methods: This study was a randomized, controlled, open-label, comparative efficacy trial. We randomly assigned patients with migraine into cupping therapy plus serkangabin group (30 patients) and conventional treatment group (30 patients). An investigator assessed the severity of headache, frequency of attacks in a week and duration of attacks per hour in 5 visits (at the end of 2 weeks, 1, 3 and 6 months). Generalized estimating equations approach was used to analyze repeated measures data to compare outcomes in both groups. INTRODUCTION Millions of people worldwide suffer from migraine. Migraine is one of the top 20 causes of disability in the world.[,] Migraine causes morbidity and bed rest in more than half of affected people. It causes a decrease in the quality of life, increased absenteeism and reduced productivity at work.

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It also increases healthcare costs.[] Migraine attack is usually managed by nonsteroidal antiinflammatory drugs, acetaminophen, 5HT 1 agonists including ergots and triptans, dopamine antagonists and sometimes opioid analgesics.[,,,,] Different medications such as β-blockers, flunarizine, valproic acid, topiramate, amitriptyline, venlafaxine, gabapentin, naproxen, butterbur root, Vitamin B 2 and magnesium are recommended for migraine prophylaxis; however, efficacy and adverse effects are still controversial.[] Many diseases especially chronic ones are neither curable nor well palliated. Existing treatments can impose serious adverse reactions and provision of care is fragmented and impersonal.[] Complementary alternative medicine (CAM) approach is frequently used today. More than 30% of Americans use CAM.[] Over the past few decades, thousands of studies have been performed via various CAM approaches. Migraine patients seek and explore both conventional and CAM approaches.[] Wet cupping is an ancient medical technique used in several contemporary societies in East Asia and the Middle East[] and it is frequently used for controlling pain.[] Types of cupping include retained cupping, flash cupping, moving cupping, wet cupping, medicinal cupping, and needling cupping.[] Wet cupping is a common method. In order to perform this procedure, a glass cup is placed on the skin and a vacuum is created inside it. After a few minutes, a superficial incision is placed in the area to suck the blood into the cup.

This is repeated several times.[] It is being used in the management of hypertension, diabetes mellitus, headaches, renal, and biliary stones and for maintaining health. Little experimental studies have been devoted to test its efficacy to treat migraine headache.